Natural Protection From Type 1 Diabetes in NOD Mice Is Characterized by a Unique Pancreatic Islet Phenotype

The NOD mouse develops spontaneous type 1 diabetes, with some features of disease that are very similar to the human disease. However, a proportion mice naturally protected from developing and currently, studies characterizing this cohort limited. Here, using both immunofluorescence multiparameter flow cytometry, we focus on pancreatic islet morphology immune infiltrate observed in mice. We show characterized by an increased frequency insulin-containing, smaller-sized, islets. Although remain diabetes free, florid remains. is skewed toward regulatory phenotype T- B-cell compartments. Pancreatic islets have IL-10–producing B cells associated cell surface markers. Resident memory CD69+CD8+ T significant shift reduced CD103 expression, while CD4+ FoxP3+CTLA4+ expression. These data indicate unique signature provide new insight into mechanisms within